Introduction of Molecular cell biology

The objectives and development of cell biology

Microscope and Cell theory

Major events in cell biology

课堂教学视频

Cell theory-test

Culturing and visualizing cells

Growing Cells in Culture

Monoclonal antibodies

Fluorescence Microscopy

Flow cytometry

Spinning Disk Confocal Microscopy

FRAP and FRET

RNA interference

The structure of CRISPR Cas9

Mechanism of CRISPR/cas9

课下阅读文献：Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus，Nature. 2003 Nov 27;426(6965):450-4

课堂教学视频

Culturing and visualizing cells-test

Biomembrane Structure

The structrures of the plasmic membrane

The lipid bilayer: Composition and structural organization

Forms of lipid molecules exist in water

Lipids Movement in biomembrane

Structure of Membrane Proteins

Synthesis of Phospholipids and Intracellular Movement

Biomembrane Structure-test

Vesicular traffic,secretion and endocytosis

Molecular Mechanisms of Vesicle Budding and Fusion

Early Stages of the Secretory Pathway

Later Stages of the Secretory Pathway

Receptor-Mediated Endocytosis

Directing Membrane Proteins and Cytosolic Materials to the Lysosome

The structure and functions of Lysosomes

Exosome

Cell Penetrating Peptides

Vesicular traffic,secretion and endocytosis

Transmembrane transport of Ions and small molecules

Overview of transmembrane transport

Facilitated Transport of Glucose and Water

ATP –powered pumps

Na+/k+ pump

Ca2+ pump

K+ channel and the Resting membrane potencial

Cotransport by Symporters and Antiporters

Transcellular transport

微课视频：急性腹泻口服补液疗法的作用机制

Transmembrane transport of Ions and small molecules

Cellular Energetics

Overview of aerobic oxidation

Structure of Mitochondria

Mitochondrial Oxidation of Fatty Acids Generates ATP

The Electron Carriers and Electron Transport Chain

The Electron Transport and Generation of the Proton-Motive Force

Chemiosmotic theory and Endosymbiont hypothesis

Harnessing the Proton-Motive Force to synthesize ATP

Electron Transport and Reactive Oxygen Species (ROS)

课外文献阅读：The molecular machinery of Keilins respiratory chain，Biochem Soc Trans. 2003 Dec;31(Pt 6):1095-105）

Cellular Energetics

Moving Proteins into Membranes and Organelles

Targeting Proteins to and Across the ER Membrane

Insertion of single-pass Proteins into the ER

Insertion of Multipass Proteins into the ER

Protein Glycosylation and Folding in the ER

Formation of disulfide bonds in the ER

Protein Quality Control in the ER

Targeting of Proteins to Mitochondria

Targeting of Peroxisomal Proteins

课下阅读文献：The Cytoplasmic Tail of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains a Novel Endoplasmic Reticulum Retrieval Signal That Binds COPI and Promotes Interaction with Membrane Protein

Cytoplasmic glycosylation --O-GlcNAcylation

Moving Proteins into Membranes and Organelles

Signal transduction and G protein-coupled receptors

Brief Introduction of Cell Communication

Signaling Molecules and Receptors

G Proteins and G Protein-coupled Receptors (GPCR)

GPCR Mediated Signaling pathways

Signal transduction

Signaling pathways that control gene activity

Outlines of Signaling pathways that control  gene activity

Phosphoinositide Signaling Pathways

TGF-b Receptors and TGFb Signaling Pathways

Signaling Pathways controlled by Ubiquitination

The Ras/MAPK and JAK/STAT signaling pathway

Signaling pathways that control gene activity

Integrating cells into tissues

第一单元 Unit 1 cell-cell and cell-matrix adhesion overview

第二单元 Unit 2 Cell adhesion molecules

第三单元 Unit 3 Cell-Cell and Cell- ECM junction Part I

第四单元 Unit 4 Cell-Cell and Cell- ECM junction Part II

第五单元 Unit 5 Extracellular Matrix

Ch20 Test -single answer choice

Stem cells, cell asymmetry

第一单元 Unit 1 An overview of Stem cells

第二单元 Unit 2 Embryonic, Adult Stem Cell and Niches

第三单元 Unit 3 Cell Polarity and Cell Asymetry

Ch21 Test- single answer Choice

Cell organization and movement II: Microtubules and intermediate filament

第一单元 Microtubule Structure and Organization

第二单元 Microtubule Dynamics

第三单元 Regulation of Microtubule Structure and Dynamics

第四单元 Kinesins & Dyneins: Microtubule-Based Motor Proteins

第五单元 Cilia & Flagella: Microtubule-Based Surface Structures

第六单元 Mitotic Spindle

第七单元 Intermediate Filaments

文献阅读材料

Cell organization and movement II: Microtubules and intermediate filament单元测验

The Eukaryotic Cell Cycle

第一单元 Unit 1, Overview of the Cell Cycle and Its Control

第二单元 Unit 2, Model Organisms to Study the Cell Cycle

第三单元 Unit 3, CDK and Regulation of CDK Activity

第四单元 Unit 4, Entry into Cell Cycle (G1-S Transition; START Transition)

第五单元 Unit 5, Entry into Mitosis (G2-M Transition)

第六单元 Unit 6, Chromosome Segregation (Metaphase-to-Anaphase Transition)

第七单元 Unit 7, Cell Cycle Checkpoints (Surveillance Mechanisms)

第八单元 Unit 8, Cell Cycle and Human Diseases-- Cancer & Down Syndrome

The Eukaryotic Cell Cycle单元测验

Cell senescence and death

What is senescence?

Characteristics of senescence

Molecular mechanism of senescence

Physio-pathological roles of Senescence

Cell death 1-apoptosis

Cell death 2-necroptosis and pyroptosis

Slides

Cell senescence and death

Cell organization and movement I: Microfilaments

Dynamic Assembly of Actin Filaments

Actin-Based Cellular Structures

Myosins and Myosin-Powered Movements

Actin Filaments

Cell organization and movement I: Microfilament