课程简介
In Biopharmaceutical and Toxicological Analysis, the goal is to achieve an in-depth understanding of the analysis of medicines and/or their metabolites, endogenous and toxic substances in biological samples. To achieve this goal, this course has adopted a multidisciplinary approach that integrates different subjects which are complementary to each other. This approach also made it possible for students to appreciate the complexity of a subject like bioanalysis. This course sheds light on preclinical and clinical pharmacokinetics, therapeutic drug monitoring, clinical pharmacy, biopharmaceutics, drug abusing analysis, and forensic science.
课程大纲
Chapter 1 Outline
Chapter 2 Basic theories related to biopharmaceutical analysis
2.1 Drug’s in vivo process – absorption and distribution
2.2 Drug’s in vivo process – metabolism and excretion
2.3 Therapeutic drug monitoring
2.4 Assignment
Chapter 3 Preparation and pretreatment of biosamples
3.1 Preparation and storage of commonly used biospecimens
3.2 Pretreatment of biospecimens (1)
3.3 Pretreatment of biospecimens (2)
3.4 Advances in pretreatment of biospecimens
3.5 Assignment
Chapter 4 Development and validation of bioanalytical method
4.1 Design and development of bioanalytical method
4.2 Bioanalytical method validation (1)
4.3 Bioanalytical method validation (2)
4.4 Assignment
Chapter 5 Chromatography and its hyphenated techniques
5.1 Hyphenated chromatography (1)
5.2 Hyphenated chromatography (2)
5.3 High performance capillary electrophoresis
5.4 Assignment
Chapter 6 Immunoassay
6.1 Immunoassay (1)
6.2 Immunoassay (2)
6.3 Immunoassay (3)
6.4 Capillary electrophoresis-based immunoassay
6.5 Assignment
Chapter 7 Cutting-edge analytical technology
7.1 Isotope analysis
7.2 Mass spectrometry imaging
7.3 Advances in Biopharmaceutical Analysis
7.4 Assignment
Chapter 8 Bioanalysis of typical medicines
8.1 Bioanalysis of biotechnological drugs
8.2 Bioanalysis of endogenous steroid hormones
Chapter 9 Bioanalysis of typical poisons
9.1 Bioanalysis of animal and plant poisons
9.2 Bioanalysis of of water-soluble poisons
Chapter 10 Bioanalysis of typical illicit drugs
10.1 Bioanalysis of drugs of abuse
Chapter 11 Virtual simulation experiment
Final examination
Chapter 2 Basic theories related to biopharmaceutical analysis
2.1 Drug’s in vivo process – absorption and distribution
2.2 Drug’s in vivo process – metabolism and excretion
2.3 Therapeutic drug monitoring
2.4 Assignment
Chapter 3 Preparation and pretreatment of biosamples
3.1 Preparation and storage of commonly used biospecimens
3.2 Pretreatment of biospecimens (1)
3.3 Pretreatment of biospecimens (2)
3.4 Advances in pretreatment of biospecimens
3.5 Assignment
Chapter 4 Development and validation of bioanalytical method
4.1 Design and development of bioanalytical method
4.2 Bioanalytical method validation (1)
4.3 Bioanalytical method validation (2)
4.4 Assignment
Chapter 5 Chromatography and its hyphenated techniques
5.1 Hyphenated chromatography (1)
5.2 Hyphenated chromatography (2)
5.3 High performance capillary electrophoresis
5.4 Assignment
Chapter 6 Immunoassay
6.1 Immunoassay (1)
6.2 Immunoassay (2)
6.3 Immunoassay (3)
6.4 Capillary electrophoresis-based immunoassay
6.5 Assignment
Chapter 7 Cutting-edge analytical technology
7.1 Isotope analysis
7.2 Mass spectrometry imaging
7.3 Advances in Biopharmaceutical Analysis
7.4 Assignment
Chapter 8 Bioanalysis of typical medicines
8.1 Bioanalysis of biotechnological drugs
8.2 Bioanalysis of endogenous steroid hormones
Chapter 9 Bioanalysis of typical poisons
9.1 Bioanalysis of animal and plant poisons
9.2 Bioanalysis of of water-soluble poisons
Chapter 10 Bioanalysis of typical illicit drugs
10.1 Bioanalysis of drugs of abuse
Chapter 11 Virtual simulation experiment
Final examination